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From March 4 to 6, 2026, Natural Products Expo West — the world's largest natural health products exhibition — concluded successfully at the Anaheim Convention Center in Anaheim, Greater Los Angeles. BIODEP made its high-profile debut at the expo with its core probiotic product portfolio, showcasing the innovative strength and technological prowess of China's probiotic sector to global business partners.   Expo Highlights at a Glance As an industry-benchmarking event with a 42-year heritage, this year's edition gathered over 3,500 exhibitors and more than 85,000 professional attendees from across the globe, with top North American buyers including Kroger, Walmart, and Amazon in full attendance. With 80% of exhibitors securing on-site trade partnerships, the expo stands as a core gateway for enterprises to tap into the hundreds-of-billions-dollar North American health and wellness market.   Standout Core Products High-Activity Patented Strains: Star strains including weight management strains, longevity-promoting strains, and Akkermansia muciniphila(AKK) were showcased on-site, with proprietary technologies reaching an internationally leading level. Multi-Scenario Solutions: A full product range covering gut health, immune modulation, and care for specific population groups, developed leveraging a strain library of over 5,000 strains and more than 60 patented technologies. The products are available in six diverse dosage forms, with full support for customized development of multi-dosage and multi-formula solutions. Full Industrial Chain Capabilities: The company presented its 100-ton-level production capacity of probiotic raw powder and competitive advantages in automated manufacturing, with its products having been exported to more than 20 countries and regions worldwide.   Through this exhibition, BIODEP has not only built a solid bridge for international cooperation, but also empowered domestic Chinese strains to step onto the global stage with "Created in China" probiotic products. Looking ahead, we will continue to deepen our dedication to the microbiology field, bringing more premium Chinese probiotic solutions to serve global health and wellness.

From October 29 to 30, 2025 (local time), the globally anticipated 2025 SupplySide Global – International Exhibition of Natural, Healthy, and Innovative Ingredients – was grandly held in Las Vegas, USA. As a leading enterprise in China’s probiotics industry, BIODEP made a remarkable appearance on this international stage, showcasing China’s innovative achievements and technological strength in the probiotics field to the world. Chinese Strength on the International Stage Recognized as the trendsetter of the global health industry, SupplySide Global is one of the largest and most influential international exhibitions in the fields of natural extracts, nutraceutical ingredients, and dietary supplements. This year’s exhibition gathered nutritional ingredient suppliers, functional food and dietary supplement brands, research institutions, and biotech enterprises from over 100 countries and regions worldwide to discuss the latest trends and future developments in the health industry. Focus on Probiotic Innovation: Technological Strength Supports Global Layout At the exhibition, BIODEP highlighted multiple innovative achievements in probiotics, including: · The anti-aging AKK strain derived from centenarians in Bama (Akkermansia muciniphila AKK-LTA21F2); · Breast milk-derived strains for infant health (Lactobacillus reuteri FPHC2951, Bifidobacterium breve FPHC4024); · Kefir-derived strains with high EPS (exopolysaccharide) production (Lactobacillus helveticus LZ-R-5,Lactobacillus plantarum T1,Lactobacillus paracasei GL1). These innovations demonstrate advanced probiotic R&D capabilities with Chinese characteristics. Additionally, BIODEP has developed unique formulations such as oil-droplet and crystal-bead delivery systems, which enhance strain stability and absorption efficiency while adapting to diverse food and beverage applications—fully reflecting its technological prowess in probiotic innovation. These achievements are built on BIODEP's solid R&D foundation and industrialization capabilities. The company's microbial bank houses approximately 2,000 strains, with over 40 commercialized strains, and leads in key technologies such as Lactobacillus plantarum viability preservation. Currently, BIODEP has achieved a hundred-ton-level production capacity for probiotic raw powder, with an annual output of 100 tons of high-activity freeze-dried powder. It operates multiple production bases and R&D centers globally, continuously supporting its international market expansion. Expanding International Cooperation to Promote Probiotic Globalization Leveraging the SupplySide Global platform, BIODEP connected with global industry leaders and professional audiences to explore potential collaborations. Its products are already exported to over 20 countries and regions, including developed markets such as the United States, Canada, and Spain. Through this exhibition, BIODEP gained first-hand insights into the latest trends and consumer demands in the global probiotics market, providing valuable input for optimizing its market strategy. The company will continue to focus on R&D and innovation in core probiotic technologies. BIODEP is committed to advancing Chinese probiotic technology onto the world stage and contributing Chinese wisdom to the global health industry.

Groundbreaking Review Reveals: How Protein-Polysaccharide "Perfect Synergy" Reshapes Taste & Health.   Introduction: Still captivated by the silky texture and health benefits of yogurt? A groundbreaking review by BIODEP and Professor Li Wei's research team at Nanjing Agricultural University, published in the top-tier food science journal 《Comprehensive Reviews in Food Science and Food Safety》(Impact Factor: 14.1, CAS Q1 Top Journal), unveils the "molecular-level" secret behind the core quality of fermented yogurt—both dairy-based and plant-based—the intricate interplay between exopolysaccharides (EPS) and proteins! This study not only delves into the complex mechanisms at work but also charts a golden path for the precision design of functional yogurts in the future.  The paper, "Recent Advances in Exopolysaccharide–Protein Interactions in Fermented Dairy- and Plant-Based Yogurts: Mechanisms, Influencing Factors, Health Benefits, Analytical Techniques, and Future Directions" systematically deciphers the "black box" of EPS-protein interactions (covering casein, whey protein, soy protein, pea protein, and more) across multiple dimensions. It reveals how this "dynamic duo" collaboratively shapes yogurt's physical structure, enhances sensory appeal, and unlocks its remarkable health potential.   Review Overview Amid the rise of plant-based diets, yogurt has expanded from dairy to diverse plant-based alternatives. Whether dairy or plant-derived, the core secret of texture lies in the "synergistic interplay" between bacterial EPS and proteins during fermentation. This review explores EPS-protein binding mechanisms, detailing multi-dimensional interactions between proteins (casein, whey, soy, pea, etc.) and EPS, and highlights their critical roles in enhancing texture, water retention, stability, and bioactivity. It further discusses factors influencing EPS-protein binding (pH, temperature, molecular structure, exogenous enzymes) and proposes future research directions for structural analysis and precision food design, providing a theoretical basis for functional fermented foods.   Core Content Highlights   (1) Mechanistic Insights: The binding between EPS and proteins is not a single interaction but involves multiple mechanisms such as charge attraction, hydrogen bonding, hydrophobic interactions, and spatial entanglement. For example, dairy-based proteins carry a positive charge under acidic conditions, facilitating the formation of stable complexes with negatively charged EPS. In contrast, plant proteins, due to their lower hydrophobicity and compact structure, often require thermal denaturation or enzymatic hydrolysis to enhance binding capacity.   (2) Quality Enhancement: EPS–protein complexes significantly improve yogurt’s viscosity, gel strength, and water-holding capacity, effectively extending shelf life and enhancing consumer sensory experiences. Particularly in plant-based yogurt, the introduction of EPS notably alleviates the bottleneck issue of "insufficient texture."   (3) Health Benefits: Beyond physical property improvements, EPS–protein complexes exhibit robust bioactivity, including antioxidant, anti-inflammatory, gut microbiota modulation, cholesterol-lowering, and blood sugar control effects, demonstrating strong potential for developing "functional foods."   (4) Technical Methods: The article also reviews various classic and cutting-edge analytical techniques, such as circular dichroism spectroscopy, Fourier-transform infrared spectroscopy, scanning electron microscopy, molecular docking, and NMR, providing methodological support for structural analysis of EPS–protein interactions.   Graphical Appreciation Figure 1 Biosynthetic pathway of capsular polysaccharide (CPS) and released exopolysaccharide (rEPS) Figure 2 Schematic diagram of EPS improving the quality of fermented dairy/plant-based yogurt after binding with proteins Figure 3 Schematic diagram of common intermolecular interactions during EPS-protein binding   Figure 4 Factors influencing the binding of EPS-protein complexes  Figure 5 Different characterization techniques for analyzing structural changes in EPS-protein complexes   Figure 6 Future research directions of EPS-protein complexes in food systems   Conclusions and Prospects The interaction between exopolysaccharides (EPS) and proteins in fermented yogurt not only determines its texture and mouthfeel but also profoundly influences its functional activity and health benefits. Research into such complex mechanisms is evolving from "sensory experience" to "precision design at the molecular level." Future studies should place greater emphasis on the network formation mechanisms under multi-component synergy, focusing on dynamic changes in real food systems. By integrating artificial intelligence and multi-omics approaches, more predictive model systems can be established. Particularly in the field of plant-based yogurt, understanding how EPS enhances protein network formation will be a key pathway to improving both texture and functionality.     Original link https://doi.org/10.1111/1541-4337.70219

Recently, the research group of Professor Li Wei, College of Food Science and Technology, Nanjing Agricultural University, together with Jiangsu Biodep Biotechnology Co.,Ltd. published a research paper titled "Effects of Lacticaseibacillus paracasei SNB-derived postbiotic components on intestinal barrier dysfunction and composition of gut microbiota" in Food Research International (Q1, IF = 8.1). The first author of this paper is Xiao Luyao, a doctoral student in the College of Food Science and Technology, Nanjing Agricultural University, and Professor Li Wei is the corresponding author. This article focuses on the probiotics-derived postbiotics and reveals the function and application potential of Lacticaseibacillus paracasei SNB-derived postbiotic components.These components protect against intestinal barrier damage, promote the proliferation of lactic acid bacteria as a major source of carbon and nitrogen, and regulate the intestinal flora positively. Research background: As we all know, intestinal flora is closely related to people's health, and many aspects of human physiological functions are affected by the complex intestinal microbiome, such as energy metabolism, intestinal barrier, immune and nervous systems. Considering the close relationship between intestinal flora and host health, dietary intervention is a common means to regulate intestinal flora. Probiotics are generally recognized as safe microorganisms. Currently, Lactobacillus and bifidobacterium are the main probiotic supplements, and the positive regulatory effects of probiotics on the host health have been fully studied. According to the consensus statement issued by the International Scientific Association for Probiotics and Prebiotics (ISAPP), postbiotics are defined as "preparations of non-living microorganisms and/or their components that are beneficial to host health," including non-living bacteria, bacterial metabolites, and/or bacteria decomposing components. Postbiotics not only act as a symbol of human immunity regulation but also a nutrient that directly produces beneficial effects on human body. They have shown a unique effect superior to probiotics and prebiotics in regulating immune response, body metabolism, nerve conduction and other functions, and have made up for the shortcomings of probiotics in storage, transportation and processing with greater and wider potentials in application. Lacticaseibacillus paracasei S-NB was isolated from traditional fermented milk in Aksu, Xinjiang, China by this lab. In previous studies, this strain showed advantages such as a high number of viable bacteria, rapid proliferation, and strong adhesion ability, etc. Whole-genome sequencing analysis, gene prediction and gene cluster analysis related to synthesis of surface macromolecules of this strain have been completed. Therefore, the study on the probiotic function evaluation of the surface components of S-NB strain and the regulation potential of intestinal flora will further promote the existing understanding of the potential functions of this strain. The objective of this study was to (1) investigate the protective mechanism of capsular polysaccharide (B-CPS) and surface protein (B-SLP) from Lacticaseibacillus paracasei S-NB derived postbiotics, on intestinal cell barrier damage; (2) evaluate whether B-CPS and B-SLP can be used as major carbon and nitrogen sources to promote the growth and proliferation of Lactobacillus of different species, respectively; (3) determine the effects of B-CPS and B-SLP on human intestinal microbial composition and SCFAs separately and unitedly. Conclusion and Prospect: In this study, the postbiotic components B-CPS and B-SLP were isolated from the surface of Lacticaseibacillus paracasei S-NB strain. First, an LPS-induced barrier damage model of Caco-2 intestinal epithelial cells was constructed, and it was confirmed that pretreatment with 100μg/mLB-CPS and B-SLP could increase the transmembrane resistance value of intestinal epithelial cells, enhance cell permeability, and increase the relative expression of tight junction protein. These results indicated that B-CPS and B-SLP were beneficial to repair the integrity of intestinal epithelial cells. In addition, it was found that the molecular weight of B-CPS and the particle size distribution of B-SLP did not change significantly after simulated gastrointestinal digestion in vitro, and B-CPS and B-SLP could serve as the main carbon and nitrogen sources, respectively, to promote the growth and proliferation of 8 different Lactobacillus strains. In vitro anaerobic fermentation experiments, B-CPS and the mixture of B-CPS and B-SLP in equal proportions could increase the abundance of beneficial intestinal flora, especially bifidobacterium, reduce the proportion of pathogens harmful to host, and promote the production of short-chain fatty acids. The correlation between environmental variables (pH, short-chain fatty acids) and the Top50 bacteria at the genus level was further analyzed, and the results showed that the level of short-chain fatty acids was positively correlated with the abundance of most beneficial bacteria. The results show that B-CPS and B-SLP, the postbiotic components of Lacticaseibacillus paracasei, have the potential to improve human intestinal health, and are expected to be further developed and applied in functional foods or health products. About the author: Li Wei, Professor, Associate Dean, doctoral Supervisor, College of Food Science and Technology, Nanjing Agricultural University; Visiting Scholar, Department of Medicine-GI/Nutrition, Harvard Medical School/Division Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Co-Supervisor: Wayne I. Lencer. He is also the deputy director of Jiangsu Province Agricultural Products Processing and Storage and Quality Control experimental teaching Demonstration Center, the secretary of the biological engineering teaching branch of Food Science and Technology College, and the head of Jiangyin Probiotic Expert Workstation of Nanjing Agricultural University. He is also a member of the third Youth Working Committee of the Chinese Society of Food Science and Technology, a director of the National Science and Technology Innovation Alliance for Food and Drug Homologous Industry, a vice chairman of the Nanjing Microbiology Society, and a member of the Youth Science and Technology Committee of Nanjing Agricultural University. He was selected as the third batch of "Zhong Shan Scholars Academic Rookie" Program of Nanjing Agricultural University (2015), "Excellent Young Backbone Teachers of Jiangsu Province Blue Project" (2016), and "Doctor of Double Innovation" (Vice President of Science and Technology) of Jiangsu Province High-level Innovation and Entrepreneurship Talent Introduction Program (2016). He was awarded the Outstanding Party Affairs Worker of Nanjing Agricultural University (2018), the "Most Beautiful Teacher" of Nanjing Southern Agricultural University (2019), and the Outstanding Contribution Award for Social Cooperation of Nanjing Agricultural University (2020). 2012-2015, 2020 unit assessment excellent, 2017 section level personnel recruitment period excellent assessment. Research areas: 1) microbial resource discovery and safety evaluation 2) Research and development of new prebiotics, probiotics and epigenetics 3) Studies on the immune activity of prebiotics, probiotics, and intestinal probiotics 4) Study on high density fermentation culture and activity preservation technology of active probiotics 5) Discovery of new resources of bacterial polysaccharides 6) Study on the function and activity of lactic acid bacteria polysaccharide.

On the morning of October 19, the 2021 Taihu Talent Summit was grandly opened. With the theme of 'New Era, New Talents, and New Ecology,' this summit focused on the need for innovation-driven and industrially strong urban development, strengthening synergy of factors, and the agglomeration of resources. It attracted more than 50 Chinese and foreign academicians, 50 well-known university leaders, 100 national-level experts, 100 outstanding local talents, and over 1,000 outstanding young talents. In addition to the opening ceremony, the conference also featured 20 talent innovation-themed activities, such as thought gatherings, acceleration camps, project roadshows, and achievement docking. The strongest voice in the era of 'Ai Cai, Xi Wang You Come.' Zhu Aixun, Deputy Secretary of the Municipal Party Committee, Du Jiangfeng, Academician of the Chinese Academy of Sciences, Member of the Standing Committee of the Party Committee, and Vice President of the University of Science and Technology of China, and Hong Hao, Vice Minister of the Organization Department of the Provincial Party Committee and Deputy Director of the Provincial Talent Office, delivered speeches respectively. Yang Bailing, former Vice President of the Chinese Academy of Sciences, Hu Wenzhong, Deputy Director and first-level inspector of the Professional and Technical Personnel Management Department of the Ministry of Human Resources and Social Security, Jiang Hong, Deputy Director of the Provincial Department of Science and Technology, academician of the Chinese Academy of Engineering, academician of the German Academy of Engineering Sciences, Sweden Academician Wu Zhiqiang of the Royal Academy of Engineering Sciences, Director of the National Center for Infectious Diseases, Director of the Department of Infectious Diseases of Fudan University Huashan Hospital Zhang Wenhong, famous economist Ren Zeping, Vice President of the Chinese Academy of Personnel Sciences Liu Xuezhi, and city leaders Zhou Minwei, Bai Changling, Wang Zuocai, Jiang Min, and Gao Yaguang attended the opening ceremony. This year, Wuxi's 'Taihu Talent Plan' has newly shortlisted 27 leading talent teams, which will receive comprehensive support such as project support, salary subsidies, and customized services like 'one enterprise, one policy.' Jiang Min, member of the Standing Committee of the Municipal Party Committee and Deputy Secretary of the municipal government, Zhang Wenhong, director of the Department of Infectious Diseases at Huashan Hospital affiliated with Fudan University, and team leader of the Department of Infectious Diseases of the Fifth People's Hospital of the city, awarded medals to the leaders of the first batch of shortlisted teams.

Congratulations to Xie Liwei, the biological research and development consultant, for securing the new bid for the Olympics Globally, the prevalence of overweight/obesity is increasing rapidly. Obesity and its complications not only seriously affect the quality of life of patients but also bring a heavy economic burden to society and families. Low carbohydrate diets (LCD) are a dietary intervention mode for weight loss therapy. However, in different studies, the weight loss effects of LCD intervention are quite different. There is currently no sufficient evidence to explain this difference. This is a qualitative phenomenon, which is also a challenging aspect in the field of medical weight management. On September 15, the teams of Professor Hong Chen and Professor Sun Jia from the Department of Endocrinology and Metabolism at Zhujiang Hospital of Southern Medical University, and Professor Xie Liwei from the Gut Microbiology and Health Team of the Guangdong Institute of Microbiology, published the clinical research report titled 'Gut microbiota serves as a predictable outcome of short-term low-carbohydrate diet (LCD) intervention for patients with obesity' in the journal Microbiology Spectrum. This study reported for the first time that the baseline characteristic of the intestinal flora is a determinant of the short-term low-carbohydrate diet (LCD) weight reduction effect in the overweight and obese population. The study builds an Artificial Neural Networks (ANN) model based on the baseline characteristics of the intestinal flora to predict the weight loss effect of LCD. The findings provide a new approach for clinical medical weight management and intervention strategies. Globally, the prevalence of overweight/obesity is increasing rapidly. Since 1980, the prevalence of obesity in more than 70 countries has doubled. The population affected by obesity or obesity-related chronic metabolic diseases has increased to more than 2 billion [1]. According to data from the National Center for Health Statistics (NCHS), from 2017 to 2018, the prevalence of obesity in the U.S. was about 42.4%, and the prevalence of severe obesity with a BMI≥40 kg/m2 reached 9.2% [2]. At the same time, the "Report on Nutrition and Chronic Disease Status of Chinese Residents (2020)" [3] pointed out that the prevalence/incidence rate of overweight and obesity among Chinese residents is still rising rapidly, and the adult population's overweight or obesity rate has exceeded 50%. Overweight/obesity is a risk factor for a series of chronic diseases such as cardiovascular disease, type 2 diabetes, cancer, etc. [4], [5], which seriously endangers the health of Chinese people [6], [7], [8]. Additionally, there are more than 29 complications such as hypertension, dyslipidemia, and glucose metabolism disorders caused by obesity in adolescents, seriously affecting the physical development and health of adolescents. For obese patients, CVDs are the main reason for the high obesity-related mortality and disability rate. The high BMI-related disability rate caused by CVDs is 34%, and the high BMI-related mortality rate is as high as 41% [9] Increasing morbidity, potential health hazards, and significant economic burden have made the problem of overweight/obesity a huge challenge in the field of global public health. In recent years, various forms of weight loss interventions have been gradually applied in clinical practice and written into guidelines. Lifestyle interventions are the cornerstone of obesity treatment, and dietary interventions are the primary choice. Among the many dietary intervention models, low-carbohydrate diet intervention has attracted much attention. It has a long history, but it has different forms. In recent years, LCD has attracted widespread attention, but there are also certain controversies. This study included 51 male or female subjects aged 18-65 who met the diagnostic criteria of overweight/obesity (no antibiotics or drugs were used in the first 3 months of the clinical trial). The subjects were randomized into groups and were divided into different groups. Energy-restricted normal diet (ND) group and non-calorie-restricted low-carbohydrate diet group (LCD). The diet intervention time was 12 weeks. In order to ensure the LCD diet structure, the LCD group adopted a standardized nutrition bar (provided by Guangzhou Nanda Feite Nutrition and Health Consulting Co., Ltd.) instead of the daily staple food for lunch and dinner. The number of other foods is not limited, and overeating is avoided. At the time of enrollment (ie baseline) and 12 weeks after the intervention, venous blood and stool samples were collected. The blood samples were used for the detection of blood biochemical indicators such as glucose and lipid metabolism, liver and kidney function, and the stool samples were used for intestinal flora 16S rDNA amplicon sequencing, through 16S rDNA amplicon sequencing, a total of 2.47 million high-quality reads were obtained. The diet of the subjects was monitored through a 24-hour diet for 3 days a week. During the entire study period, the average proportion of carbohydrate intake in the normal diet group was about 50%, and the proportion in the LCD group was about 20% (Figure 1B-D). Although calorie intake was not restricted, the average energy intake of the low-carbon group was about 50%. Enrollment was significantly lower than that of the normal diet group. The 12-week LCD intervention significantly improved the subjects` body parameters such as BMI, waist circumference, waist circumference, body fat percentage, and visceral fat area. In addition to different weight loss results, different dietary components may affect the composition and diversity of the intestinal flora, but apart from changes in the overall composition and phyla level, previous studies have not drawn a constructive conclusion to guide LCD Therefore, we have analyzed the intestinal flora sequencing data, and adopted 5-fold cross-validation and random forest algorithm, taking into account the minimum error rate and standard deviation to ensure the highest accuracy and stability. Next, we analyzed the 16S rDNA sequence data of subjects in the ND and LCD groups before and after the test to identify potential biomarkers of flora. A further analysis of all the genus screened by the random forest model in baseline and week 12 data found that the relative abundance of Ruminococcaceae Oscillospira and Porphyromonadaceae Parabacteroides increased significantly after the 12-week LCD intervention, and the difference was statistically significant (p< 0.05). According to existing research reports, these two species of bacteria are involved in the production of butyrate in the intestine, suggesting that there may be other factors affecting weight changes during the process of LCD intervention in weight loss. Further analyze the weight loss of each subject, and divide each group into two subgroups according to the clustering of weight loss parameters: BMI, waist circumference, WHR, BFR and VFA changes: a moderated weight loss effect. weight loss group (MG) and significant weight loss group (distinct weight loss group, DG). Under the conditions of LCD intervention, the energy intake and the proportion of carbohydrates in the diet of the two subgroups were almost the same, but the weight loss indexes of the subjects in the markedly effective subgroup decreased more significantly, suggesting that the individualized differences in weight loss effects may be affected by other factors. Influence The above results suggest that LCD intervention has a good weight loss effect, but there are individual differences. Therefore, this study further analyzed the intestinal flora data of the two subgroups, and further explored whether there are potential factors related to the flora that caused the difference in weight loss between the two subgroups in this diet. In further subgroup analysis, we used the co-occurrence network at the genus level to further analyze the interaction between the intestinal flora in the LCD subgroup and found that after 12 weeks of LCD intervention, although the two subgroups LCD_DG and LCD_MG The network interaction complexity of the network has decreased, but LCD_DG showed a denser, more extensive and richer network interaction complexity than LCD_MG in the baseline and at the 12th week. The above results indicate that, in addition to the differences in the composition and diversity of the flora, the differences between the structure of the flora and the complexity of the interaction of the flora may be an important reason for the individual differences in the weight loss effect. In the low-carbon subgroup, analysis by the random forest model algorithm found that the baseline relative abundance of Bacteroidaceae Bacteroides was statistically different in the two subgroups of the low-carbon diet. According to linear regression analysis, we found the baseline of Bacteroidaceae Relative abundance is positively correlated with the weight loss effect of short-term low-carbon diet. Based on the above results, the ROC model was established based on the baseline relative abundance of the low-carbon subgroup of Bacteroides. The ROC model reflects the susceptibility of each data point on the curve to the same signal stimulus and comprehensively reflects the sensitivity and specificity of the variables. In this study, the ROC model AUC value reached 73.2%, suggesting that the baseline relative abundance of Bacteroides has a certain predictive value for the short-term low-carbohydrate diet weight loss effect. Since the flora in the human intestine is not an independent individual, there are intricate connections between bacteria. Therefore, this research introduces artificial neural network (ANN). ANN is a more powerful deep learning model that is trained and used to simulate biological neural networks for complex data analysis. ANN is based on biological neural networks. The basic principle of the network, imitating the human brain structure and external stimulus response mechanism, building a model based on the knowledge of network topology, has the functions of associative memory, classification and recognition, optimized calculation and nonlinear mapping. In recent years, more and more medical researches apply ANN to the processing of complex data. We incorporated the change values and ratios of the weight loss parameters of the LCD group into the ANN model based on the baseline relative abundance of the overall intestinal flora of the group, and obtained a higher predictive model determination coefficient (R2), which also indicates the prediction of ANN The effect is better than the linear model, suggesting that the prediction effect is better. All in all, the current research shows that in overweight/obese people, short-term LCD intervention without calorie restriction has a significant weight loss effect without significant adverse effects. There are individual differences in short-term LCD weight loss. The relative abundance of Bacteroidaceae Bacteroides at baseline before LCD intervention is positively correlated with the short-term LCD intervention weight loss effect. Finally, this study constructed a high-precision ANN prediction model based on the relative abundance of the intestinal flora at the baseline. Through the ANN prediction model, it was found that the baseline relative abundance of the intestinal flora can be used as a predictor of the individualized weight loss effect before LCD intervention. , It has important guiding significance for clinical medicine weight management. Related research results were published in "Microbiology Spectrum". Based on the results of this research, in clinical medicine weight management, the relative abundance of Bacteroidaceae Bacteroides in the intestines is relatively low, but the overweight/obese subjects who hope to lose weight through LCD may increase the weight loss of LCD by supplementing the corresponding Probiotics. Efficacy. At present, our research group is working with the Guangdong Academy of Sciences Institute of Microbiology and Xie Liwei Research Institute team to carry out clinical weight loss research on the combined use of probiotics and low-carbon diet to further explore the strategies and ideas of medical weight management. Let us look forward to the updated research Results. The main author of this study is Zhang Susu, a physician in the Department of Endocrinology and Metabolism, Zhujiang Hospital, Southern Medical University; Co-first author, Wu Peili, PhD candidate in the Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University; Tian is also a Ph.D., Department of Endocrinology and Metabolism, Zhujiang Hospital, Southern Medical University, Chen Hong The professor and researcher Xie Liwei of the State Key Laboratory of Applied Microbiology in South China jointly cultivated master students; Liu Bingdong is a joint training of PhD students by Professor Pan Jiyang from the Department of Psychiatry of the First Affiliated Hospital of Jinan University and researcher Xie Liwei of the State Key Laboratory of Applied Microbiology in South China. The corresponding author of this article is Professor Sun Jia from the Department of Endocrinology and Metabolism, Zhujiang Hospital of Southern Medical University, and the co-corresponding authors are Professor Chen Hong from the Department of Endocrinology and Metabolism, Zhujiang Hospital of Southern Medical University, and researcher PI Xie Liwei from the Intestinal Microecology and Health Team of the Institute of Microbiology, Guangdong Academy of Sciences.

The nationwide fight against the epidemic is about to usher in victory. Although the number of new cases of the coronavirus abroad is still increasing, we believe that science and technology, scientific applications, and scientific inclusiveness can speed up the fight against the epidemic. We also wish the victory of this global fight against the epidemic come soon. This professional review shared with you today will officially open a new scene in the era of [post-anti-epidemic] Biooda Biosciences serving the society. As a bioscience company that integrates probiotic research, production and supply, Biodep Biosciences began to plan research on the intestinal and chronic diseases of middle-aged and elderly people at the beginning of its establishment. "A Review of the Brain-Gut-Microbiome Axis and the Potential Role of Microbiota in Alzheimer's Disease" was published in the "Journal of Alzheimer's Disease" in November 2019. This article is about Alzheimer's disease. The relationship between (Alzheimer's disease, AD) and the intestinal flora was discussed and elaborated in depth. Biodep is a gift for the health of all mankind. The BIOGG compound Probiotics combination formula strives to become a good solution to human chronic diseases. It will provide help to people in need of AD (Alzheimer's Disease), sports injuries, and overall immunity. Partners in the application field of related products, welcome you to meet again at the FIC conference this year to discuss the future of [Scientific Anti-aging]!